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Article

Silencing of Anticoagulant Protein C Evokes Low-Incident but Spontaneous Atherothrombosis in Apolipoprotein E-Deficient Mice-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2017

Ouweneel Amber B, Heestermans Marco, Verwilligen Robin A F, Gijbels Marion J J, Reitsma Pieter H, Van Eck Miranda, van Vlijmen Bart J M

Abstract excerpt

OBJECTIVE: Murine atherosclerosis models do not spontaneously develop atherothrombotic complications. We investigated whether disruption of natural anticoagulation allows preexisting atherosclerotic plaques to progress toward an atherothrombotic phenotype. APPROACH AND RESULTS: On lowering of plasma protein C levels with small interfering RNA (siProc) in 8-week Western-type diet-fed atherosclerotic apolipoprotein...

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Identifiers

PMID: 28302625
DOI: 10.1161/ATVBAHA.117.309188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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