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Atherosclerotic lesions in mouse and man: is it the same disease?

30 Jul 2010

Abstract excerpt

PURPOSE OF REVIEW: Genetically-engineered mice with hyperlipidemia are the most widely used atherosclerosis models today, but recent advances in transgenesis open the possibility to create new models in alternative species, such as the rat and pig. It seems relevant at this point in time to review some of the strengths and weaknesses of the mouse. RECENT FINDINGS: The histology of lesion development in mouse and...

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PMID: 20683327
DOI: 10.1097/mol.0b013e32833ded6a

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