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Article

Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia.

Blood - 1 Oct 2006

Dayal Sanjana, Wilson Katina M, Leo Lorie, Arning Erland, Bottiglieri Teodoro, Lentz Steven R

Abstract excerpt

Hyperhomocysteinemia is a risk factor for thrombosis, but the mechanisms are not well defined. We tested the hypothesis that hyperhomocysteinemia accelerates arterial thrombosis in mice. Mice heterozygous for a targeted disruption of the cystathionine beta-synthase gene (Cbs+/-) and wild-type littermates (Cbs+/+) were fed either a control diet or a high methionine/low folate (HM/LF) diet for 6 to 8 months to...

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Identifiers

PMID: 16804115
DOI: 10.1182/blood-2006-02-005991
PMCID: PMC1895559

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