Article
Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation.
Journal of the American Heart Association - 7 Jul 2020
Chen Daxin, Li Ke, Festenstein Sam, Karegli Julieta, Wilkinson Hannah, Leonard Hugh, Wei Lin-Lin, Ma Ning, Xia Min, Tam Henry, Wang Jian-An, Xu Qingbo, McVey John H, Smith Richard A G, Dorling Anthony
Abstract excerpt
Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel thrombin inhibitor, PTL060, comprising hirulog covalently linked to a synthetic myristoyl electrostatic switch to tether to cell membranes. Methods and Results ApoE-/- mice were fed chow or high-fat diets, before transplantation of congenic aortic segments...
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