Article
Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
PloS one - 1 Jan 2013
Borissoff Julian I, Otten Jeroen J T, Heeneman Sylvia, Leenders Peter, van Oerle René, Soehnlein Oliver, Loubele Sarah T B G, Hamulyák Karly, Hackeng Tilman M, Daemen Mat J A P, Degen Jay L, Weiler Hartmut, Esmon Charles T, van Ryn Joanne, Biessen Erik A L, Spronk Henri M H, ten Cate Hugo
Abstract excerpt
BACKGROUND: Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded contradictory findings on the role of hypercoagulability in atherogenesis. We therefore sought to address this matter by extensively investigating the in vivo...
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