Article
Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production.
Blood - 23 May 2013
Safdar Huma, Cheung Ka Lei, Salvatori Daniela, Versteeg Henri H, Laghmani El Houari, Wagenaar Gerry T M, Reitsma Pieter H, van Vlijmen Bart J M
Abstract excerpt
Mice deficient in the anticoagulants antithrombin (Serpinc1) or protein C (Proc) display premature death due to thrombosis-related coagulopathy, thereby precluding their use in gene function studies and thrombosis models. We used RNA interference to silence Serpinc1 and/or Proc in normal adult mice. The severe coagulopathy that followed combined "knockdown" of these genes is reported. Two days after siRNA...
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