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Article

Deletion of tenascin-C gene exacerbates atherosclerosis and induces intraplaque hemorrhage in Apo-E-deficient mice.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

Wang Lai, Wang Wei, Shah Prediman K, Song Lei, Yang Mingjie, Sharifi Behrooz G

Abstract excerpt

AIMS: Tenascin-C (TNC), a matricellular protein, is up-regulated in atherosclerotic plaques. We investigated whether the deletion of TNC gene affects the development of atherosclerosis in a murine model. METHODS: TNC-/-/apo E-/- mice were generated and used for atherosclerosis studies. We compared these results to those observed in control groups of apo E-/- mice. RESULTS: The en face analysis of aortic area...

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Source

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Identifiers

PMID: 22300502
DOI: 10.1016/j.carpath.2011.12.005
PMCID: PMC3345312

Genes

TNC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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