Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

doi:10.1126/scitranslmed.aai7514

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Science translational medicine - 15 Mar 2017

Bonsignori Mattia, Kreider Edward F, Fera Daniela, Meyerhoff R Ryan, Bradley Todd, Wiehe Kevin, Alam S Munir, Aussedat Baptiste, Walkowicz William E, Hwang Kwan-Ki, Saunders Kevin O, Zhang Ruijun, Gladden Morgan A, Monroe Anthony, Kumar Amit, Xia Shi-Mao, Cooper Melissa, Louder Mark K, McKee Krisha, Bailer Robert T, Pier Brendan W, Jette Claudia A, Kelsoe Garnett, Williams Wilton B, Morris Lynn, Kappes John, Wagh Kshitij, Kamanga Gift, Cohen Myron S, Hraber Peter T, Montefiori David C, Trama Ashley, Liao Hua-Xin, Kepler Thomas B, Moody M Anthony, Gao Feng, Danishefsky Samuel J, Mascola John R, Shaw George M, Hahn Beatrice H, Harrison Stephen C, Korber Bette T, Haynes Barton F

Abstract excerpt

A preventive HIV-1 vaccine should induce HIV-1-specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to acquire breadth, and current vaccine strategies have not been successful in inducing bnAbs. Because bnAbs directed against a glycosylated site adjacent to the third variable loop (V3) of the HIV-1 envelope protein require limited SHM, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Neutralizing

Share to Crystallography, X-Ray

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV-1

Share to Neutralization Tests

Share to Phylogeny

Share to Polysaccharides

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 28298420
DOI: 10.1126/scitranslmed.aai7514
PMCID: PMC5562350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.PMID 28298420Read ↗

Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope.Semantic proximity Read ↗

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen DesignSemantic proximity Read ↗

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.Semantic proximity Read ↗

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus MacaqueSemantic proximity Read ↗

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection.Semantic proximity Read ↗

Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.Semantic proximity Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.Semantic proximity Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutationsSemantic proximity Read ↗

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.Semantic proximity Read ↗

Long-term and low-level envelope C2V3 stimulation from highly diverse virus isolates leads to frequent development of broad and elite antibody neutralization in HIV-1 infected individualsSemantic proximity Read ↗

Functional development of a V3-specific broadly neutralizing antibody isolated from a case of HIV superinfectionSemantic proximity Read ↗

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.