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Article

Genetic, Epigenetic, and Microenvironmental Drivers of Cholangiocarcinoma.

The American journal of pathology - 1 Mar 2025

Putatunda Vijay, Jusakul Apinya, Roberts Lewis, Wang Xin Wei

Abstract excerpt

Cholangiocarcinoma (CCA) is an aggressive and heterogeneous malignancy of the biliary tree that carries a poor prognosis. Multiple features at the genetic, epigenetic, and microenvironmental levels have been identified to better characterize CCA carcinogenesis. Genetic alterations, such as mutations in IDH1/2, BAP1, ARID1A, and FGFR2, play significant roles in CCA pathogenesis, with variations across different...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39532242
DOI: 10.1016/j.ajpath.2024.10.013
PMCID: PMC11841490

Genes

ARID1A
BAP1
FGFR2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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