Next-generation sequencing analysis of cholangiocarcinoma identifies distinct IDH1-mutated clusters.

doi:10.1016/j.ejca.2022.08.026

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Next-generation sequencing analysis of cholangiocarcinoma identifies distinct IDH1-mutated clusters.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2022

Rimini Margherita, Loi Eleonora, Fabregat-Franco Carles, Burgio Valentina, Lonardi Sara, Niger Monica, Scartozzi Mario, Raposelli Ilario G, Aprile Giuseppe, Ratti Francesca, Pedica Federica, Verdaguer Helena, Rizzato Mario, Nichetti Federico, Lai Eleonora, Cappetta Alessandro, Macarulla Teresa, Fassan Matteo, De Braud Filippo, Pretta Andrea, Simionato Francesca, De Cobelli Francesco, Aldrighetti Luca, Fornaro Lorenzo, Cascinu Stefano, Zavattari Patrizia, Casadei-Gardini Andrea

Abstract excerpt

BACKGROUND: IDH1-mutated intrahepatic cholangiocarcinomas (IDH1m iCCAs) could be treated with anti-IDH1 drugs, although the high heterogeneity in this class of tumours could limit treatment efficacy. METHODS: We selected 125 IDH1m iCCAs that were treated as resectable, locally advanced, or metastatic and were screened by the NGS-based FoundationOne gene panel. We conducted a mutation-based clustering of tumours...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Duct Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Ducts, Intrahepatic

Share to Cholangiocarcinoma

Share to Chromatin

Share to High-Throughput Nucleotide Sequencing

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Phosphatidylinositol 3-Kinases

Source

Open in PubMed

Identifiers

PMID: 36182816
DOI: 10.1016/j.ejca.2022.08.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next-generation sequencing analysis of cholangiocarcinoma identifies distinct IDH1-mutated clusters.PMID 36182816Read ↗

Molecular profile and its clinical impact of IDH1 mutated versus IDH1 wild type intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Impact of IDH1 mutation on clinical course of patients with intrahepatic cholangiocarcinoma: a retrospective analysis from a German tertiary center.Semantic proximity Read ↗

Mutation Rate of IDH1 and the Impact of Pathological Features on Survival in Intrahepatic CholangiocarcinomaSemantic proximity Read ↗

Molecular Profile and Prognostic Value of BAP1 Mutations in Intrahepatic Cholangiocarcinoma: A Genomic Database AnalysisSemantic proximity Read ↗

Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for InterventionSemantic proximity Read ↗

Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing.Semantic proximity Read ↗

Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.Semantic proximity Read ↗

Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma.Semantic proximity Read ↗

Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilities.Semantic proximity Read ↗

Association of IDH1 mutations with survival and recurrence in resected intrahepatic cholangiocarcinoma received or not received adjuvant chemotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.