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Article

Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers.

Cancer research - 4 Jun 2024

Liao Haotian, Chen Xing, Wang Haichuan, Lin Youpei, Chen Lu, Yuan Kefei, Liao Mingheng, Jiang Hanyu, Peng Jiajie, Wu Zhenru, Huang Jiwei, Li Jiaxin, Zeng Yong

Abstract excerpt

Intrahepatic cholangiocarcinoma (iCCA) is the second most prevalent primary liver cancer. Although the genetic characterization of iCCA has led to targeted therapies for treating tumors with FGFR2 alterations and IDH1/2 mutations, only a limited number of patients can benefit from these strategies. Epigenomic profiles have emerged as potential diagnostic and prognostic biomarkers for improving the treatment of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38471085
DOI: 10.1158/0008-5472.CAN-23-3298
PMCID: PMC11148548

Genes

FGFR2
IDH1
BAP1
GBP4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers.PMID 38471085Read ↗

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