Article
Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Feb 2025
Gilbert T M, Randle L, Quinn M, McGreevy O, O'leary L, Young R, Diaz-Neito R, Jones R P, Greenhalf B, Goldring C, Fenwick S, Malik H, Palmer D H
Abstract excerpt
Cholangiocarcinoma (CCA) remains a devastating malignancy and a significant challenge to treat. The majority of CCA patients are diagnosed at an advanced stage, making the disease incurable in most cases. The advent of high-throughput genetic sequencing has significantly improved our understanding of the molecular biology underpinning cancer. The identification of 'druggable' genetic aberrations and the...
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