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Article

Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil.

PLoS neglected tropical diseases - 1 Jan 2015

de Araujo Felipe Jules, da Silva Luan Diego Oliveira, Mesquita Tirza Gabrielle, Pinheiro Suzana Kanawati, Vital Wonei de Seixas, Chrusciak-Talhari Anette, Guerra Jorge Augusto de Oliveira, Talhari Sinésio, Ramasawmy Rajendranath

Abstract excerpt

INTRODUCTION: The clinical outcome to Leishmania-infection is determined by the individual adaptive immune T helper cell responses and their interactions with parasitized host cells. An early development of a proinflammatory immune response (Th1 response) is necessary for Leishmania-infection resolution. The Toll-interacting protein (TOLLIP) regulates human Toll-like receptors signaling pathways by down...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26107286
DOI: 10.1371/journal.pntd.0003875
PMCID: PMC4479602

Genes

TOLLIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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