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Article

Minimized natural versions of fungal ribotoxins show improved active site plasticity.

Archives of biochemistry and biophysics - 1 Apr 2017

Maestro-López Moisés, Olombrada Miriam, García-Ortega Lucía, Serrano-González Daniel, Lacadena Javier, Oñaderra Mercedes, Gavilanes José G, Martínez-Del-Pozo Álvaro

Abstract excerpt

Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein biosynthesis by interfering with elongation factors. Most ribotoxins show high degree of conservation, with similar sizes and amino acid sequence identities above 85%. Only two exceptions are known: hirsutellin A and anisoplin, produced by the entomopathogenic...

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PMID: 28283321
DOI: 10.1016/j.abb.2017.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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