Analysis by systematic deletion of amino acids of the action of the ribotoxin restrictocin.

doi:10.1016/s0167-4838(01)00290-4

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Article

Analysis by systematic deletion of amino acids of the action of the ribotoxin restrictocin.

Biochimica et biophysica acta - 31 Jan 2002

Glück Anton, Wool Ira G

Abstract excerpt

A series of contiguous deletions were made in a cDNA encoding the ribonuclease restrictocin with the purpose of identifying the amino acids that are essential for the cleavage of the phosphodiester bond on the 3' side of G4325 in the alpha-sarcin/ricin domain of mammalian (rat) 28S rRNA. In all 93 of 149 amino acids, 62% of the residues in restrictocin, were not essential for the action of the toxin. Of the five...

Topics

Allergens
Amino Acid Sequence
Amino Acids
Animals
Antigens, Plant
Cytotoxins
DNA, Complementary
Fungal Proteins
Gene Deletion
Lysine
Molecular Sequence Data
Mutation
Plasmids
Protein Structure, Secondary
RNA, Ribosomal, 28S
Rabbits
Rats
Reticulocytes

Source

Open in PubMed

Identifiers

PMID: 11825614
DOI: 10.1016/s0167-4838(01)00290-4

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