Involvement of loops L2 and L4 of ribonucleolytic toxin restrictocin in its functional activity.

doi:10.2174/092986607779816131

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Article

Involvement of loops L2 and L4 of ribonucleolytic toxin restrictocin in its functional activity.

Protein and peptide letters - 1 Jan 2007

Dey Punyatirtha, Tripathi Manisha, Batra Janendra K

Abstract excerpt

Restrictocin, a member of the fungal ribotoxin family, specifically cleaves a single phosphodiester bond in the 28S rRNA and potently inhibits eukaryotic protein synthesis. The long loops in restrictocin molecule have been shown structurally to be involved in target RNA recognition. In this study we have investigated the role of some putative substrate-interacting residues in loops L2 and L4, spanning residues...

Topics

Amino Acid Substitution
Circular Dichroism
Fungal Proteins
HeLa Cells
Humans
Lysine
Mutagenesis, Site-Directed
Mutation
Mycotoxins
Proline
Protein Synthesis Inhibitors
RNA
RNA, Ribosomal, 28S
Recombinant Proteins
Ribonucleases
Serine
Structure-Activity Relationship
Substrate Specificity

Source

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Identifiers

PMID: 17305598
DOI: 10.2174/092986607779816131

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