Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Scientific reports - 10 Mar 2017

Rallis Charalampos, Townsend StJohn, Bähler Jürg

Abstract excerpt

The Target of Rapamycin (TOR) signalling network plays important roles in aging and disease. The AMP-activated protein kinase (AMPK) and the Gsk3 kinase inhibit TOR during stress. We performed genetic interaction screens using synthetic genetic arrays (SGA) with gsk3 and amk2 as query mutants, the latter encoding the regulatory subunit of AMPK. We identified 69 negative and 82 positive common genetic interactors,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Antifungal Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Glycogen Synthase Kinase 3

Share to Mechanistic Target of Rapamycin Complex 1

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Sirolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 28281664
DOI: 10.1038/srep44257
PMCID: PMC5345095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.PMID 28281664Read ↗

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.Semantic proximity Read ↗

The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1.Semantic proximity Read ↗

Rapalink-1 reveals novel mTOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating mTOR activity and lifespanSemantic proximity Read ↗

Synthetic genetic array analysis for global mapping of genetic networks in yeast.Semantic proximity Read ↗

Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae.Semantic proximity Read ↗

Modulators of MAPK pathway activity during filamentous growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast.Semantic proximity Read ↗

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactionsSemantic proximity Read ↗

Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.Semantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiaeSemantic proximity Read ↗

Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.