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Article

Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast.

Open biology - 1 Mar 2018

Sajiki Kenichi, Tahara Yuria, Villar-Briones Alejandro, Pluskal Tomáš, Teruya Takayuki, Mori Ayaka, Hatanaka Mitsuko, Ebe Masahiro, Nakamura Takahiro, Aoki Keita, Nakaseko Yukinobu, Yanagida Mitsuhiro

Abstract excerpt

Rapamycin inhibits TOR (target of rapamycin) kinase, and is being used clinically to treat various diseases ranging from cancers to fibrodysplasia ossificans progressiva. To understand rapamycin mechanisms of action more comprehensively, 1014 temperature-sensitive (ts) fission yeast (Schizosaccharomyces pombe) mutants were screened in order to isolate strains in which the ts phenotype was rescued by rapamycin....

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Identifiers

PMID: 29593117
DOI: 10.1098/rsob.170261
PMCID: PMC5881033

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