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Article

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae

1 Dec 2013

Abstract excerpt

Current approaches for identifying synergistic targets use cell culture models to see if the combined effect of clinically available drugs is better than predicted by their individual efficacy. New techniques are needed to systematically and rationally identify targets and pathways that may be synergistic targets. Here, we created a tool to screen and identify molecular targets that may synergize with new...

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PMID: 24360963
DOI: 10.1016/j.celrep.2013.11.040

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Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiaePMID 24360963Read ↗

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chipsSemantic proximity Read ↗

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Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p.Semantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes.Semantic proximity Read ↗

Identification of TOR signaling complexes: more TORC for the cell growth engine.Semantic proximity Read ↗

Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read ↗

TORC1 signaling is governed by two negative regulators in fission yeast.Semantic proximity Read ↗

Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.Semantic proximity Read ↗

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.Semantic proximity Read ↗

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae.Semantic proximity Read ↗

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