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Article

The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1.

Cell reports - 10 Mar 2020

Rodríguez-López María, Gonzalez Suam, Hillson Olivia, Tunnacliffe Edward, Codlin Sandra, Tallada Victor A, Bähler Jürg, Rallis Charalampos

Abstract excerpt

Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well studied, while analogous transcriptional regulation is less understood. Here we screen fission yeast mutants for resistance to Torin1, which inhibits TORC1 and cell growth....

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Identifiers

PMID: 32160533
DOI: 10.1016/j.celrep.2020.02.058
PMCID: PMC7068653

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