Article
Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Wang Xin Xiang, Li Yili, Yin Yiyuan, Mo Min, Wang Qian, Gao Wei, Wang Lili, Mariuzza Roy A
Abstract excerpt
Helper T-cell activation generally requires the coreceptor CD4, which binds MHC class II molecules. A remarkable feature of the CD4-MHC class II interaction is its exceptionally low affinity, which ranges from K(D) = ∼200 μM to >2 mM. Investigating the biological role of the much lower affinity of this interaction than those of other cell-cell recognition molecules will require CD4 mutants with enhanced binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.