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Article

Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.

Structure (London, England : 1993) - 1 Nov 2016

Liu Weifeng, Ramagopal Udupi, Cheng Huiyong, Bonanno Jeffrey B, Toro Rafael, Bhosle Rahul, Zhan Chenyang, Almo Steven C

Abstract excerpt

The apoptotic effect of FasL:Fas signaling is disrupted by DcR3, a unique secreted member of the tumor necrosis factor receptor superfamily, which also binds and neutralizes TL1A and LIGHT. DcR3 is highly elevated in patients with various tumors and contributes to mechanisms by which tumor cells to evade host immune surveillance. Here we report the crystal structure of FasL in complex with DcR3. Comparison of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27806260
DOI: 10.1016/j.str.2016.09.009

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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