Article
Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology.
Die Pharmazie - 1 Feb 2010
Nomura T, Abe Y, Kamada H, Inoue M, Kawara T, Arita S, Furuya T, Minowa K, Yoshioka Y, Shibata H, Kayamuro H, Yamashita T, Nagano K, Yoshikawa T, Mukai Y, Nakagawa S, Tsunoda S, Tsutsumi Y
Abstract excerpt
Tumor necrosis factor-alpha (TNF), which binds two types of TNF receptors (TNFR1 and TNFR2), regulates the onset and exacerbation of autoimmune diseases such as rheumatoid arthritis and Crohn's disease. In particular, TNFR1-mediated signals are predominantly related to the induction of inflammatory responses. We have previously generated a TNFR1-selective antagonistic TNF-mutant (mutTNF) and shown that mutTNF...
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