Article
A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell.
The Journal of biological chemistry - 9 Feb 2018
Hashiramoto Akira, Konishi Yoshitake, Murayama Koichi, Kawasaki Hiroki, Yoshida Kohsuke, Tsumiyama Ken, Tanaka Kimie, Mizuhara Masaru, Shiotsuki Toshio, Kitamura Hitomi, Komai Koichiro, Kimura Tomoatsu, Yagita Hideo, Shiozawa Kazuko, Shiozawa Shunichi
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic polyarthritis of unknown etiology. To unravel the molecular mechanisms in RA, we performed targeted DNA sequencing analysis of patients with RA. This analysis identified a variant of the death receptor 3 (DR3) gene, a member of the family of apoptosis-inducing Fas genes, which contains four single-nucleotide polymorphisms (SNPs) and a 14-nucleotide deletion within exon 5 and...
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