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Article

SIDT2 mediates gymnosis, the uptake of naked single-stranded oligonucleotides into living cells.

RNA biology - 2 Nov 2017

Takahashi Masayuki, Contu Viorica Raluca, Kabuta Chihana, Hase Katsunori, Fujiwara Yuuki, Wada Keiji, Kabuta Tomohiro

Abstract excerpt

Single-stranded oligonucleotides (ssOligos) are efficiently taken up by living cells without the use of transfection reagents. This phenomenon called 'gymnosis' enables the sequence-specific silencing of target genes in various types of cells. Several antisense ssOligos are used for the treatment of human diseases. However, the molecular mechanism underlying the uptake of naked ssOligos into cells remains to be...

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Source

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Identifiers

PMID: 28277980
DOI: 10.1080/15476286.2017.1302641
PMCID: PMC5785214

Genes

SIDT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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