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Antisense technology: A review

1 Jan 2021

Abstract excerpt

Antisense technology is beginning to deliver on the broad promise of the technology. Ten RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double-strand ASOs (siRNAs) have now been approved for commercial use, and the ASOs in phase 2/3 trials are innovative, delivered by multiple routes of administration and focused on both rare and common diseases. In fact, two ASOs are used in...

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Identifiers

PMID: 33600796
DOI: 10.1016/j.jbc.2021.100416

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