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Antisense Oligonucleotides: Treatment Strategies and Cellular Internalization

7 Nov 2016

Abstract excerpt

The clinical applicaton of antisense oligonucleotides (ASOs) is becoming more of a reality as several drugs have been approved for the treatment of human disorders and many others are in various phases in development and clinical trials. ASOs are short DNA/RNA oligos which are heavily modified to increase their stability in biological fluids and retain the properties of creating RNA-RNA and DNA-RNA duplexes that...

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PMID: 28374018
DOI: 10.14800/rd.1393

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