Microinjection of antisense oligonucleotides into living mouse testis enables lncRNA function study

Abstract excerpt

BACKGROUND: Long non-coding RNAs (lncRNAs) have been the focus of ongoing research in a diversity of cellular processes. LncRNAs are abundant in mammalian testis, but their biological function remains poorly known. RESULTS: Here, we established an antisense oligonucleotides (ASOs)-based targeting approach that can efficiently knock down lncRNA in living mouse testis. We cloned the full-length transcript of lncRNA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related molecular mechanisms research
• Share to Sperm and Testicular Function
• Share to Testicular diseases and treatments