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Article

siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference.

Genes - 23 Aug 2021

Fang Zhiming, Zhao Zhongming, Eapen Valsamma, Clarke Raymond A

Abstract excerpt

Exogenous siRNAs are commonly used to regulate endogenous gene expression levels for gene function analysis, genotype-phenotype association studies and for gene therapy. Exogenous siRNAs can target mRNAs within the cytosol as well as nascent RNA transcripts within the nucleus, thus complicating siRNA targeting specificity. To highlight challenges in achieving siRNA target specificity, we targeted an overlapping...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34440463
DOI: 10.3390/genes12081290
PMCID: PMC8393430

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