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Article

Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.

The Journal of biological chemistry - 21 Apr 2006

Dejima Katsufumi, Seko Akira, Yamashita Katsuko, Gengyo-Ando Keiko, Mitani Shohei, Izumikawa Tomomi, Kitagawa Hiroshi, Sugahara Kazuyuki, Mizuguchi Souhei, Nomura Kazuya

Abstract excerpt

Sulfation of biomolecules, which is widely observed from bacteria to humans, plays critical roles in many biological processes. All sulfation reactions in all organisms require activated sulfate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS), as a universal donor. In animals, PAPS is synthesized from ATP and inorganic sulfate by the bifunctional enzyme, PAPS synthase. In mammals, genetic defects in PAPS synthase...

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PMID: 16497669
DOI: 10.1074/jbc.M601509200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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