Article

A Half-Century History of Applications of Antisense Oligonucleotides in Medicine, Agriculture and Forestry: We Should Continue the Journey

2018-05-31

Abstract excerpt

Antisense oligonucleotides (ASO), short single-stranded polymers based on DNA or RNA chemistries and synthesized in vitro, regulate gene expression by binding in a sequence-specific manner to an RNA target. The functional activity and selectivity in the action of ASOs largely depends on the combination of nitrogenous bases in a target sequence. This simple and natural property of nucleic acids provides an attracti...

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Literature Corpus work: ca1e14cd-3705-5737-80bd-8c37eb380c15
DOI: 10.20944/preprints201804.0322.v2

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