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Article

Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints.

Nature communications - 6 Mar 2017

Chan Yvonne H, Venev Sergey V, Zeldovich Konstantin B, Matthews C Robert

Abstract excerpt

Sequence divergence of orthologous proteins enables adaptation to environmental stresses and promotes evolution of novel functions. Limits on evolution imposed by constraints on sequence and structure were explored using a model TIM barrel protein, indole-3-glycerol phosphate synthase (IGPS). Fitness effects of point mutations in three phylogenetically divergent IGPS proteins during adaptation to temperature...

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Identifiers

PMID: 28262665
DOI: 10.1038/ncomms14614
PMCID: PMC5343507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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