Modeling Sequence-Space Exploration and Emergence of Epistatic Signals in Protein Evolution.

Abstract excerpt

During their evolution, proteins explore sequence space via an interplay between random mutations and phenotypic selection. Here, we build upon recent progress in reconstructing data-driven fitness landscapes for families of homologous proteins, to propose stochastic models of experimental protein evolution. These models predict quantitatively important features of experimentally evolved sequence libraries, like...

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