Multiple peaks and reciprocal sign epistasis in an empirically determined genotype-phenotype landscape.

Abstract excerpt

Insight into the ruggedness of adaptive landscapes is central to understanding the mechanisms and constraints that shape the course of evolution. While empirical data on adaptive landscapes remain scarce, a handful of recent investigations have revealed genotype-phenotype and genotype-fitness landscapes that appeared smooth and single peaked. Here, we used existing in vivo measurements on lac repressor and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Biological Evolution
• Share to Epistasis, Genetic