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Article

Heterogeneity of the GFP fitness landscape and data-driven protein design.

eLife - 5 May 2022

Gonzalez Somermeyer Louisa, Fleiss Aubin, Mishin Alexander S, Bozhanova Nina G, Igolkina Anna A, Meiler Jens, Alaball Pujol Maria-Elisenda, Putintseva Ekaterina V, Sarkisyan Karen S, Kondrashov Fyodor A

Abstract excerpt

Studies of protein fitness landscapes reveal biophysical constraints guiding protein evolution and empower prediction of functional proteins. However, generalisation of these findings is limited due to scarceness of systematic data on fitness landscapes of proteins with a defined evolutionary relationship. We characterized the fitness peaks of four orthologous fluorescent proteins with a broad range of sequence...

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Identifiers

PMID: 35510622
DOI: 10.7554/eLife.75842
PMCID: PMC9119679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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