Evolutionary mechanisms studied through protein fitness landscapes.

doi:10.1016/j.sbi.2018.01.001

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Article

Evolutionary mechanisms studied through protein fitness landscapes.

Current opinion in structural biology - 1 Feb 2018

Canale Aneth S, Cote-Hammarlof Pamela A, Flynn Julia M, Bolon Daniel Na

Abstract excerpt

Biology has, and continues to be, shaped by evolutionary mechanisms. Within the past decade, local fitness landscapes have become experimentally tractable and are providing new perspectives on evolutionary mechanisms. Powered by next-generation sequencing, the impacts of all individual amino acid substitutions on function have been quantified for dozens of proteins. These fitness maps have been utilized to...

Topics

Adaptation, Physiological
Amino Acid Substitution
Drug Resistance
Epistasis, Genetic
Evolution, Molecular
Genetic Fitness
High-Throughput Nucleotide Sequencing
Humans
Mitogen-Activated Protein Kinase 1
Mutation
Protein Conformation
Protein Folding
Protein Stability

Source

Open in PubMed

Identifiers

PMID: 29351890
DOI: 10.1016/j.sbi.2018.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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