Article
The biochemical architecture of an ancient adaptive landscape.
Science (New York, N.Y.) - 21 Oct 2005
Lunzer Mark, Miller Stephen P, Felsheim Roderick, Dean Antony M
Abstract excerpt
Molecular evolution is moving from statistical descriptions of adaptive molecular changes toward predicting the fitness effects of mutations. Here, we characterize the fitness landscape of the six amino acids controlling coenzyme use in isopropylmalate dehydrogenase (IMDH). Although all natural IMDHs use nicotinamide adenine dinucleotide (NAD) as a coenzyme, they can be engineered to use nicotinamide adenine...
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