Article
Local fitness landscape of the green fluorescent protein.
Nature - 19 May 2016
Sarkisyan Karen S, Bolotin Dmitry A, Meer Margarita V, Usmanova Dinara R, Mishin Alexander S, Sharonov George V, Ivankov Dmitry N, Bozhanova Nina G, Baranov Mikhail S, Soylemez Onuralp, Bogatyreva Natalya S, Vlasov Peter K, Egorov Evgeny S, Logacheva Maria D, Kondrashov Alexey S, Chudakov Dmitry M, Putintseva Ekaterina V, Mamedov Ilgar Z, Tawfik Dan S, Lukyanov Konstantin A, Kondrashov Fyodor A
Abstract excerpt
Fitness landscapes depict how genotypes manifest at the phenotypic level and form the basis of our understanding of many areas of biology, yet their properties remain elusive. Previous studies have analysed specific genes, often using their function as a proxy for fitness, experimentally assessing the effect on function of single mutations and their combinations in a specific sequence or in different sequences....
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