Article
Designing bacterial signaling interactions with coevolutionary landscapes.
PloS one - 1 Jan 2018
Cheng Ryan R, Haglund Ellinor, Tiee Nicholas S, Morcos Faruck, Levine Herbert, Adams Joseph A, Jennings Patricia A, Onuchic José N
Abstract excerpt
Selecting amino acids to design novel protein-protein interactions that facilitate catalysis is a daunting challenge. We propose that a computational coevolutionary landscape based on sequence analysis alone offers a major advantage over expensive, time-consuming brute-force approaches currently employed. Our coevolutionary landscape allows prediction of single amino acid substitutions that produce functional...
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