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Article

The SMX DNA Repair Tri-nuclease

1 Mar 2017

Abstract excerpt

The efficient removal of replication and recombination intermediates is essential for the maintenance of genome stability. Resolution of these potentially toxic structures requires the MUS81-EME1 endonuclease, which is activated at prometaphase by formation of the SMX tri-nuclease containing three DNA repair structure-selective endonucleases: SLX1-SLX4, MUS81-EME1, and XPF-ERCC1. Here we show that SMX...

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PMID: 28257701
DOI: 10.1016/j.molcel.2017.01.031

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