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MutSβ Stimulates Holliday Junction Resolution by the SMX Complex

1 Oct 2020

Abstract excerpt

MutSα and MutSβ play important roles in DNA mismatch repair and are linked to inheritable cancers and degenerative disorders. Here, we show that MSH2 and MSH3, the two components of MutSβ, bind SLX4 protein, a scaffold for the assembly of the SLX1-SLX4-MUS81-EME1-XPF-ERCC1 (SMX) trinuclease complex. SMX promotes the resolution of Holliday junctions (HJs), which are intermediates in homologous recombinational...

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PMID: 33086055
DOI: 10.1016/j.celrep.2020.108289

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