Article

An investigation into the interplay between MutSβ and SLX4 complexes in DNA recombination and repair

2020-01-01

Abstract excerpt

The efficient cleavage of branched DNA intermediates that arise during DNA replication, recombination or repair is essential for the maintenance of genomic stability. Human SLX4 is a scaffold protein for the assembly and activation of three structure selective endonucleases (SSEs) that cleave branched DNA structures - SLX1, MUS81-EME1 and XPF-ERCC1 (collectively known as the SMX complex). These endonucleases have...

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Literature Corpus work: 3352d5ee-f378-5cc0-b85e-3033fe3851ac
DOI: 10.25560/89087

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