Article
Molecular Mechanisms of ARID5B-Mediated Genetic Susceptibility to Acute Lymphoblastic Leukemia.
Journal of the National Cancer Institute - 9 Sept 2022
Zhao Xujie, Qian Maoxiang, Goodings Charnise, Zhang Yang, Yang Wenjian, Wang Ping, Xu Beisi, Tian Cheng, Pui Ching-Hon, Hunger Stephen P, Raetz Elizabeth A, Devidas Meenakshi, Relling Mary V, Loh Mignon L, Savic Daniel, Li Chunliang, Yang Jun J
Abstract excerpt
BACKGROUND: There is growing evidence for the inherited basis of susceptibility to childhood acute lymphoblastic leukemia (ALL). Genome-wide association studies have identified non-coding ALL risk variants at the ARID5B gene locus, but their exact functional effects and the molecular mechanism linking ARID5B to B-cell ALL leukemogenesis remain largely unknown. METHODS: We performed targeted sequencing of ARID5B...
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