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Article

Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases.

Nucleic acids research - 18 Feb 2016

Esyunina Daria, Turtola Matti, Pupov Danil, Bass Irina, Klimašauskas Saulius, Belogurov Georgiy, Kulbachinskiy Andrey

Abstract excerpt

RNA cleavage by bacterial RNA polymerase (RNAP) has been implicated in transcriptional proofreading and reactivation of arrested transcription elongation complexes but its molecular mechanism is less understood than the mechanism of nucleotide addition, despite both reactions taking place in the same active site. RNAP from the radioresistant bacterium Deinococcus radiodurans is characterized by highly efficient...

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Identifiers

PMID: 26733581
DOI: 10.1093/nar/gkv1521
PMCID: PMC4756841

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