Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

1 Jul 2003

Abstract excerpt

A hallmark of Alzheimer's disease is the deposition of plaques of amyloid beta peptide (Abeta) in the brain. Abeta is thought to be formed from the amyloid precursor protein (APP) in cholesterol-enriched membrane rafts, and cellular cholesterol depletion decreases Abeta formation. The liver X receptors (LXR) play a key role in regulating genes that control cellular cholesterol efflux and membrane composition and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol and Lipid Metabolism
Share to Drug Transport and Resistance Mechanisms
Share to Endoplasmic Reticulum Stress and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12754201
DOI: 10.1074/jbc.m300760200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide SecretionPMID 12754201Read ↗

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptorsSemantic proximity Read ↗

Role of LXR and ABCA1 in the Pathogenesis of Alzheimers Disease -Implications for a New Therapeutic ApproachSemantic proximity Read ↗

Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.Semantic proximity Read ↗

Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's diseaseSemantic proximity Read ↗

Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.Semantic proximity Read ↗

Liver-X receptor β-selective agonist CE9A215 regulates Alzheimer’s disease- associated pathology in a 3xTg-AD mouse modelSemantic proximity Read ↗

Brain single-cell transcriptional responses to bexarotene-activated RXR in Alzheimer’s disease modelSemantic proximity Read ↗

Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux.Semantic proximity Read ↗

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.Semantic proximity Read ↗

Minireview: liver X receptor beta: emerging roles in physiology and diseases.Semantic proximity Read ↗

Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer’s disease mice: Potential role in chronic heavy alcohol feedingSemantic proximity Read ↗

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.