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Article

Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.

The Journal of biological chemistry - 31 Oct 2014

Tai Leon M, Koster Kevin P, Luo Jia, Lee Sue H, Wang Yue-Ting, Collins Nicole C, Ben Aissa Manel, Thatcher Gregory R J, LaDu Mary Jo

Abstract excerpt

Previous data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist, reduces soluble and insoluble amyloid-β (Aβ) in Alzheimer disease (AD)-transgenic mice either by increasing the levels of mouse apolipoprotein E (apoE) or increasing ABCA1/ABCG1-induced apoE lipoprotein association/lipidation. However, although the mechanism of action of RXR agonists remains unclear, a major concern for their use...

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Identifiers

PMID: 25217640
DOI: 10.1074/jbc.M114.600833
PMCID: PMC4215234

Genes

ABCA1
ABCG1
APOE

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