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Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOE

25 Jun 2016

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by amyloid plaques, composed of amyloid-beta peptide (Aβ) and neurofibrillary tangles, composed of aberrantly phosphorylated tau. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 12- fold with a double allele compared to APOE3. In contrast, APOE2 reduces AD risk ~2-fold per allele. Accumulating evidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27320328
DOI: 10.2174/1568026616666160617090227

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