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Article

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration.

Biochimica et biophysica acta - 1 Aug 2010

Koldamova Radosveta, Fitz Nicholas F, Lefterov Iliya

Abstract excerpt

ATP-binding cassette transporter A1 - ABCA1, is the most extensively studied transporter in human pathology. ABCA1 became a primary subject of research in many academic and pharmaceutical laboratories immediately after the discovery that mutations at the gene locus cause severe familial High Density Lipoprotein (HDL) deficiency and, in the homozygous form - Tangier disease. The protein is the major regulator of...

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Identifiers

PMID: 20188211
DOI: 10.1016/j.bbalip.2010.02.010
PMCID: PMC3712769

Genes

ABCA1
APOE

Provenance

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