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Article

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 May 2010

Fitz Nicholas F, Cronican Andrea, Pham Tam, Fogg Allison, Fauq Abdul H, Chapman Robert, Lefterov Iliya, Koldamova Radosveta

Abstract excerpt

High-fat diet and certain dietary patterns are associated with higher incidence of sporadic Alzheimer's disease (AD) and cognitive decline. However, no specific therapy has been suggested to ameliorate the negative effects of high fat/high cholesterol levels on cognition and amyloid pathology. Here we show that in 9-month-old APP23 mice, a high-fat/high-cholesterol (HF) diet provided for 4 months exacerbates the...

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Identifiers

PMID: 20484628
DOI: 10.1523/JNEUROSCI.1051-10.2010
PMCID: PMC2883862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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