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Article

The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids.

Neurobiology of disease - 15 Oct 2022

Oun Asmaa, Sabogal-Guaqueta Angelica Maria, Galuh Sekar, Alexander Anastasia, Kortholt Arjan, Dolga Amalia M

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disease affecting elderly people. Pathogenic mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) are the most common cause of autosomal dominant PD. LRRK2 activity is enhanced in both familial and idiopathic PD, thereby studies on LRRK2-related PD research are essential for understanding PD pathology. Finding an appropriate model to mimic PD...

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PMID: 35963526
DOI: 10.1016/j.nbd.2022.105837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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